Sleep and wake are fundamental behavioral states whose molecular regulation remains
mysterious. Brain states and body functions change dramatically between sleep and wake …

Neuronal activity and gene expression in response to the loss of sleep can provide a
window into the enigma of sleep function. Sleep loss is associated with brain differential …

Abstract Study Objectives: Microarray studies have identified numerous genes that change
in response to prolonged wakefulness. The challenge is to determine which transcriptional …

Neuropeptides have central roles in the regulation of homoeostatic behaviours such as
sleep and feeding. Caenorhabditis elegans displays sleep-like quiescence of locomotion …

Sleep is a highly conserved state across the animal kingdom. However, sleep duration,
behavior and associated neural activity show great diversity across taxonomic groups, and …

The nematode Caenorhabditis elegans stops feeding and moving during a larval transition
stage called lethargus and following exposure to cellular stressors. These behaviors have …

Sleep and wakefulness are complex, tightly regulated behaviors that occur in virtually all
animals. With recent exciting developments in neuroscience methodologies such as …

The sleep–wake cycle is determined by circadian and sleep homeostatic processes.
However, the molecular impact of these processes and their interaction in different brain cell …

Although it is widely accepted that sleep must serve an essential biological function, little is
known about molecules that underlie sleep regulation. Given that insomnia is a common …

Sleep intensity is adjusted by the length of previous awake time, and under tight homeostatic
control by protein phosphorylation. Here, we establish microglia as a new cellular …