Humans have been fascinated by sleep for millennia. After almost a century of scientific
interrogation, significant progress has been made in understanding the neuronal regulation …

Sleep is nearly ubiquitous throughout the animal kingdom, yet little is known about how
ecological factors or perturbations to the environment shape the duration and timing of …

Although considered an inactive state for centuries, sleep entails many active processes
occurring at the cellular, circuit and organismal levels. Over the last decade, several key …

Sleep contributes to cognitive functioning and is sufficient to alter brain morphology and
function. However, mechanisms underlying sleep regulation remain poorly understood. In …

The mammalian basal forebrain (BF) has important roles in controlling sleep and
wakefulness, but the underlying neural circuit remains poorly understood. We examined the …

Sleep is thought to be controlled by two main processes: a circadian clock that primarily
regulates sleep timing and a homeostatic mechanism that detects and responds to sleep …

Various behavioral and cognitive states exhibit circadian variations in animals across phyla
including Drosophila melanogaster, in which only~ 0.1% of the brain's neurons contain …

Considerable evidence indicates that sleep is essential for learning and memory.
Drosophila melanogaster has emerged as a novel model for studying sleep. We previously …

Sleep is under homeostatic control, whereby increasing wakefulness generates sleep need
and triggers sleep drive. However, the molecular and cellular pathways by which sleep need …

Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review
current perspectives on the neural systems that regulate sleep/wake states in mammals and …