Sleep is crucial for survival and well-being. This behavioral and physiological state has
been studied in all major genetically accessible model animals, including rodents, fish, flies …

Many mammalian species, including humans, spend a substantial fraction of their life
sleeping. Sleep deprivation in rats ultimately leads to death, indicating the essential role of …

Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review
current perspectives on the neural systems that regulate sleep/wake states in mammals and …

Here, we propose an original approach to explain one of the great unresolved questions in
animal biology: what is the function of sleep? Existing ecological and neurological …

Why we sleep remains one of the enduring unanswered questions in biology. At its core,
sleep can be defined behaviorally as a homeostatically regulated state of reduced …

Sleep is a highly conserved state across the animal kingdom. However, sleep duration,
behavior and associated neural activity show great diversity across taxonomic groups, and …

Sleep is widely recognized as essential, but without a clear singular function. Inadequate
sleep impairs cognition, metabolism, immune function, and many other processes. Work in …

The need to sleep is sensed and discharged in a poorly understood process that is
homeostatically controlled over time. In flies, different contributions to this process have …

Sleep is a fundamental conserved physiological state in animals and humans. It may serve
multiple functions, ranging from energy conservation to higher brain operation …

Highlights•Potassium channel dynamics control excitability of sleep-promoting neurons in
flies.•The Drosophila ellipsoid body and dorsal fan-shaped body interact to drive sleep …