Chemotherapy resistance frequently drives tumor progression. Increased expression of
ST8SIA4 has been reported in diverse carcinomas and highly correlates with leukemia …

Abstract miR-302a have been reported to participate in various physiological and
pathological processes, however, a role for miR-302a in etoposide (VP-16) resistance of …

MicroRNAs (miRNAs) are involved in various processes from the development to drug
resistance of tumors, including chronic myeloid leukemia (CML). In this study, we examined …

The relapse and resistance to cytarabine (Ara-C) therapy is still a dominating obstacle to the
successful clinical treatment of acute myeloid leukemia (AML). Recent studies have shown …

Imatinib mesylate (IM) is a frontline treatment in the early chronic phase of chronic myeloid
leukemia (CML). However, intrinsic and acquired resistance against this drug has been …

BCR-ABL oncoprotein stimulates cell proliferation and inhibits apoptosis in chronic myeloid
leukemia (CML). For cure, imatinib is a widely used tyrosine kinase inhibitor, but developing …

Background and objective: Chemotherapy plays an important role in the treatment of
leukemia. Multidrug resistance (MDR) induced by chemotherapy always leads to treatment …

Acquired resistance to imatinib is frequently associated with poor clinical outcome of chronic
myeloid leukemia (CML) patient. To date, evidence indicates that protein glycosylation and …

Chronic myeloid leukemia (CML) is caused by the constitutively active BCR-ABL tyrosine
kinase. Although great progress has been made for improvement in clinical treatment during …

Despite gemcitabine being the leading chemotherapeutic drug for pancreatic cancer, many
patients still relapse due to the drug resistance. We previously reported the molecular link …