DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma

S Udali, P Guarini, A Ruzzenente, A Ferrarini… - Clinical …, 2015 - Springer
Background Alcohol is a well-known risk factor for hepatocellular carcinoma (HCC), but the
mechanisms underlying the alcohol-related hepatocarcinogenesis are still poorly …

Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake

MP Lambert, A Paliwal, T Vaissière, I Chemin… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is one of the most frequent
human cancers and a major cause of cancer-related death worldwide. The major risk factors …

[HTML][HTML] Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis

RA Hlady, RL Tiedemann, W Puszyk, I Zendejas… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths
worldwide. Deregulated DNA methylation landscapes are ubiquitous in human cancers …

Sex and race-related DNA methylation changes in hepatocellular carcinoma

W Ye, S Siwko, RYL Tsai - International journal of molecular sciences, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is the sixth most common cancer and fourth leading cause
of cancer-related death worldwide. The number of HCC cases continues to rise despite …

[PDF][PDF] Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma

N Nishida, M Kudo, T Nagasaka, I Ikai, A Goel - Hepatology, 2012 - Wiley Online Library
We aimed to identify the specific subset of tumor suppressor genes (TSGs) that are
methylation‐silenced during the earliest steps of hepatocarcinogenesis, and to further …

Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors

H Hernandez-Vargas, MP Lambert, F Le Calvez-Kelm… - PloS one, 2010 - journals.plos.org
Background Hepatocellular carcinoma (HCC) is characterized by late detection and fast
progression, and it is believed that epigenetic disruption may be the cause of its molecular …

[PDF][PDF] DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma

A Villanueva, A Portela, S Sayols, C Battiston… - …, 2015 - Wiley Online Library
Epigenetic deregulation has emerged as a driver in human malignancies. There is no clear
understanding of the epigenetic alterations in hepatocellular carcinoma (HCC) and of the …

Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma

MA Song, M Tiirikainen, S Kwee, G Okimoto, H Yu… - PloS one, 2013 - journals.plos.org
Background Hepatocellular carcinoma (HCC) is one of the most common cancers and
frequently presents with an advanced disease at diagnosis. There is only limited knowledge …

Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma

DF Calvisi, S Ladu, A Gorden, M Farina… - The Journal of …, 2007 - Am Soc Clin Investig
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, accounting for
an estimated 600,000 deaths annually. Aberrant methylation, consisting of DNA …

Epigenetic changes affecting the development of hepatocellular carcinoma

E Wolinska, M Skrzypczak - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma is a life-threatening disease. Despite many
efforts to understand the exact pathogenesis and the signaling pathways involved in its …