Antidepressants have been widely used to treat neuropathic pain for many years. However,
the mechanisms of their analgesic actions are little known and remain controvertible. Recent …

Abstract Background Neuropathic pain (NeuP) is a chronic and challenging clinical problem,
with little effective treatment. Resveratrol has shown neuroprotection by inhibiting …

This study examined the effects of turmeric bioactive compounds, curcumin C3
complex®(CUR) and bisdemethoxycurcumin (BDMC), on mechanical hypersensitivity and …

Autism is a neurodevelopmental disorder characterized by deficits in qualitative impairments
in communication, repetitive and social interaction, restricted, and stereotyped patterns of …

Aim Peripheral nerve injury upregulates tumor necrosis factor (TNF) expression. In turn,
connexin 43 (Cx43) expression in spinal astrocytes is downregulated by TNF. Therefore …

Background As a complex nervous system disease, migraine causes severe healthy and
social issues worldwide. Valproate (VPA) is a widely used treatment agent against seizures …

Central sensitization is a crucial mechanism underlying the increased excitability of
nociceptive pathways following peripheral tissue injury and inflammation. We have …

Microglia-mediated neuroinflammation plays an important role in Alzheimer's disease
development. Resveratrol, a natural polyphenol from the Japanese knotweed (Polygonum …

Chronic inflammatory pain is a severe clinical problem that greatly affects patients' quality of
life and causes huge economic burden. Microglia-mediated neuroinflammation exerts …

Background The present study directly addresses the roles of the P2X7 receptor (P2X7R),
an ionotropic adenosine triphosphate (ATP) receptor, and cytokines in the induction of …