Quantitative in vivo proteomics of metformin response in liver reveals AMPK-dependent and-independent signaling networks
Metformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on
glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity …
glucose and lipid metabolism in metabolic tissues, leading to enhanced insulin sensitivity …
Genomic characterization of metformin hepatic response
MR Luizon, WL Eckalbar, Y Wang, SL Jones… - PLoS …, 2016 - journals.plos.org
Metformin is used as a first-line therapy for type 2 diabetes (T2D) and prescribed for
numerous other diseases. However, its mechanism of action in the liver has yet to be …
numerous other diseases. However, its mechanism of action in the liver has yet to be …
Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities
Background The biguanide drug metformin is a safe and widely prescribed drug for type 2
diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role …
diabetes. Interestingly, hundreds of clinical trials have been set to evaluate the potential role …
Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action
Metformin is a biguanide drug that is widely prescribed for type 2 diabetes. Metformin
suppresses hepatic gluconeogenesis and increases fatty acid oxidation. Although studies …
suppresses hepatic gluconeogenesis and increases fatty acid oxidation. Although studies …
Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα
Background Metformin is a first-line drug for treating type 2 diabetes and has gained
considerable interest as a potential anticancer agent. Increasing evidence suggests that …
considerable interest as a potential anticancer agent. Increasing evidence suggests that …
An energetic tale of AMPK-independent effects of metformin
RA Miller, MJ Birnbaum - The Journal of clinical …, 2010 - Am Soc Clin Investig
Metformin has become a mainstay in the modest therapeutic armamentarium for the
treatment of the insulin resistance of type 2 diabetes mellitus. Although metformin functions …
treatment of the insulin resistance of type 2 diabetes mellitus. Although metformin functions …
Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex
S Meng, J Cao, Q He, L Xiong, E Chang… - Journal of Biological …, 2015 - ASBMB
Metformin is the most widely prescribed oral anti-diabetic agent. Recently, we have shown
that low metformin concentrations found in the portal vein suppress glucose production in …
that low metformin concentrations found in the portal vein suppress glucose production in …
The importance of the AMPK gamma 1 subunit in metformin suppression of liver glucose production
Metformin has been used to treat patients with type 2 diabetes for over 60 years, however, its
mechanism of action is still not completely understood. Our previous reports showed that …
mechanism of action is still not completely understood. Our previous reports showed that …
[HTML][HTML] Metformin: from mechanisms of action to therapies
Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …
Metabolic regulation by the intestinal metformin-AMPK axis
AMP-activated protein kinase (AMPK) mediates the glucose-lowering effect of the
antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of …
antidiabetic agent metformin, but the sites of action remain unclear. In the March issue of …