Lessons learned from immunological characterization of nanomaterials at the Nanotechnology Characterization Laboratory

MA Dobrovolskaia - Frontiers in Immunology, 2022 - frontiersin.org
Nanotechnology carriers have become common in pharmaceutical products because of
their benefits to drug delivery, including reduced toxicities and improved efficacy of active …

Current understanding of interactions between nanoparticles and the immune system

MA Dobrovolskaia, M Shurin, AA Shvedova - Toxicology and applied …, 2016 - Elsevier
The delivery of drugs, antigens, and imaging agents benefits from using nanotechnology-
based carriers. The successful translation of nanoformulations to the clinic involves thorough …

Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines

MA Dobrovolskaia, SE McNeil - Journal of controlled release, 2013 - Elsevier
Preclinical characterization of novel nanotechnology-based formulations is often challenged
by physicochemical characteristics, sterility/sterilization issues, safety and efficacy. Such …

In Vitro Assays for Monitoring Nanoparticle Interaction with Components of the Immune System

MA Dobrovolskaia, SE McNeil - Handbook of immunological …, 2013 - World Scientific
Preclinical immunotoxicity studies are usually conducted to identify potential causes for
concern before a new drug or a medical device is used in clinical trials. Traditionally, these …

Pre-clinical immunotoxicity studies of nanotechnology-formulated drugs: Challenges, considerations and strategy

MA Dobrovolskaia - Journal of Controlled Release, 2015 - Elsevier
Assorted challenges in physicochemical characterization, sterilization, depyrogenation, and
in the assessment of pharmacology, safety, and efficacy profiles accompany pre-clinical …

Immunological properties of engineered nanomaterials

MA Dobrovolskaia, SE McNeil - Nature nanotechnology, 2007 - nature.com
Most research on the toxicology of nanomaterials has focused on the effects of nanoparticles
that enter the body accidentally. There has been much less research on the toxicology of …

Understanding the immunogenicity and antigenicity of nanomaterials: Past, present and future

AN Ilinskaya, MA Dobrovolskaia - Toxicology and applied pharmacology, 2016 - Elsevier
Nanoparticle immunogenicity and antigenicity have been under investigation for many
years. During the past decade, significant progress has been made in understanding what …

Immunological properties of engineered nanomaterials: An introduction

MA Dobrovolskaia, SE McNeil - HANDBOOK OF IMMUNOLOGICAL …, 2016 - World Scientific
Clear benefits of using engineered nanoparticles for biomedical applications are often
challenged by concerns about the safety of these materials. Since the main job of the …

Interactions of nanomaterials with the immune system

S Hussain, JAJ Vanoirbeek… - Wiley Interdisciplinary …, 2012 - Wiley Online Library
Abstract Evaluation of the immunomodulatory potentials of nanomaterials is essential for
developing safe and consumer‐friendly nanotechnology. Various nanomaterials interact …

Immunophenotyping: analytical approaches and role in preclinical development of nanomedicines

HS Newton, MA Dobrovolskaia - Advanced drug delivery reviews, 2022 - Elsevier
Pharmaceutical products can activate immune cells, suppress their function, or change the
immune responses to traditional immunologically active agonists such as those present in …