Mesenchymal stem cells for bone repair and metabolic bone diseases

AH Undale, JJ Westendorf, MJ Yaszemski… - Mayo clinic …, 2009 - Elsevier
Human mesenchymal stem cells offer a potential alternative to embryonic stem cells in
clinical applications. The ability of these cells to self-renew and differentiate into multiple …

The combined use of mesenchymal stromal cells and scaffolds for bone repair.

G Ciapetti, D Granchi, N Baldini - Current pharmaceutical design, 2012 - europepmc.org
A general principle of stem cell therapy is to exploit the natural ability of the human body to
heal through the process of regeneration. Here, we review the current status of cell therapy …

Differentiation of osteoblasts and osteocytes from mesenchymal stem cells

TJ Heino, TA Hentunen - Current stem cell research & therapy, 2008 - ingentaconnect.com
Mesenchymal stem cells (MSCs) are multipotent cells that arise from the mesenchyme
during development. They reside in the bone marrow close to hematopoietic stem cell …

Concise review: musculoskeletal stem cells to treat age-related osteoporosis

J Kiernan, JE Davies, WL Stanford - Stem Cells Translational …, 2017 - academic.oup.com
Abstract Age-related (type-II) osteoporosis is a common and debilitating condition driven in
part by the loss of bone marrow (BM) mesenchymal stromal cells (MSC) and their osteoblast …

[HTML][HTML] The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors

P Benisch, T Schilling, L Klein-Hitpass, SP Frey… - 2012 - journals.plos.org
Primary osteoporosis is an age-related disease characterized by an imbalance in bone
homeostasis. While the resorptive aspect of the disease has been studied intensely, less is …

[HTML][HTML] Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022 - Springer
Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

Bone regeneration and stem cells

K Arvidson, BM Abdallah, LA Applegate… - Journal of cellular …, 2011 - Wiley Online Library
Introduction• Bone fracture healing and healing problems• Biomaterial scaffolds and tissue
engineering in bone formation‐Bone tissue engineering‐Biomaterial scaffolds‐Synthetic …

The role of mesenchymal stem cells in maintenance and repair of bone

R Bielby, E Jones, D McGonagle - Injury, 2007 - Elsevier
The maintenance of stable bone mass during adult life, following rapid skeletal growth
during childhood, is the result of a carefully controlled balance between the activities of bone …

Osteogenic differentiation of human marrow-derived mesenchymal stem cells

PJ Marie, O Fromigué - Regenerative medicine, 2006 - Taylor & Francis
Bone marrow-derived mesenchymal stem cells (MSCs) are adherent cells that differentiate
into chondroblasts, osteoblasts and adipocytes. In this short review, we summarize the …

Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology

E Gómez‐Barrena, P Rosset, I Müller… - Journal of cellular …, 2011 - Wiley Online Library
Introduction• Characterization of cells for bone regeneration in human beings• State of the
art in bone tissue engineering‐Biomaterials for scaffolding mesenchymal stem cells‐Future …