Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing

H Lin, J Sohn, H Shen, MT Langhans, RS Tuan - Biomaterials, 2019 - Elsevier
Bone has well documented natural healing capacity that normally is sufficient to repair
fractures and other common injuries. However, the properties of bone change throughout …

Signaling pathways involved in osteogenesis and their application for bone regenerative medicine

A Hayrapetyan, JA Jansen… - … Engineering Part B …, 2015 - liebertpub.com
Bone regeneration is a well organized but complex physiological process, in which different
cell types and their activated signaling pathways are involved. In bone regeneration and …

Impact of age on human adipose stem cells for bone tissue engineering

D Dufrane - Cell Transplantation, 2017 - journals.sagepub.com
Bone nonunion is a pathological condition in which all bone healing processes have
stopped, resulting in abnormal mobility between 2 bone segments. The incidence of bone …

[HTML][HTML] Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts

M Fakhry, E Hamade, B Badran, R Buchet… - World journal of stem …, 2013 - ncbi.nlm.nih.gov
Bone is a dynamic tissue that is constantly renewed by the coordinated action of two cell
types, ie., the bone-resorbing osteoclasts and the bone-forming osteoblasts. However, in …

Role of mesenchymal stem cells in bone regenerative medicine: what is the evidence?

A Oryan, A Kamali, A Moshiri… - Cells Tissues …, 2017 - karger.com
Healing and regeneration of bone injuries, particularly those that are associated with large
bone defects, are a complicated process. There is growing interest in the application of …

Osteogenic differentiation in healthy and pathological conditions

MT Valenti, L Dalle Carbonare, M Mottes - International journal of …, 2016 - mdpi.com
This review focuses on the osteogenic differentiation of mesenchymal stem cells (MSC),
bone formation and turn-over in good and ill skeletal fates. The interacting molecular …

Clinical application of bone marrow mesenchymal stem/stromal cells to repair skeletal tissue

A Arthur, S Gronthos - International journal of molecular sciences, 2020 - mdpi.com
There has been an escalation in reports over the last decade examining the efficacy of bone
marrow derived mesenchymal stem/stromal cells (BMSC) in bone tissue engineering and …

Efficacy of bone marrow–derived stem cells in strengthening osteoporotic bone in a rabbit model

Z Wang, J Goh, SD De, Z Ge, H Ouyang… - Tissue …, 2006 - liebertpub.com
Osteoporosis might be due to defects in mesenchymal stem cells (MSCs) that lead to
reduced proliferation and osteoblast differentiation. We hypothesized that transplantation of …

Bone cells and their role in physiological remodeling

GBM Maciel, RM Maciel, CC Danesi - Molecular Biology Reports, 2023 - Springer
Purpose: This work compiles the characteristics of bone cells involved in the physiological
bone remodeling. Methods: A narrative review of the literature was performed. Results …

Using mesenchymal stem cells as a therapy for bone regeneration and repairing

J Shao, W Zhang, T Yang - Biological research, 2015 - Springer
Bone is a unique tissue which could regenerate completely after injury rather than heal itself
with a scar. Compared with other tissues the difference is that, during bone repairing and …