Bone marrow stromal cells (bone marrow-derived multipotent mesenchymal stromal cells) for bone tissue engineering: basic science to clinical translation

H Kagami, H Agata, A Tojo - The international journal of biochemistry & cell …, 2011 - Elsevier
Bone tissue engineering is a promising field of regenerative medicine in which cultured
cells, scaffolds, and osteogenic inductive signals are used to regenerate bone. This …

The osteocyte as a therapeutic target in the treatment of osteoporosis

GY Rochefort - Therapeutic advances in musculoskeletal …, 2014 - journals.sagepub.com
Osteoporosis is characterized by a low bone-mineral density associated with skeletal
fractures. The decrease in bone-mineral density is the consequence of an unbalanced bone …

Human mesenchymal stem cell–derived matrices for enhanced osteoregeneration

S Zeitouni, U Krause, BH Clough… - Science translational …, 2012 - science.org
The methodology for the repair of critical-sized or non-union bone lesions has unpredictable
efficacy due in part to our incomplete knowledge of bone repair and the biocompatibility of …

Osteoblastic cells: differentiation and trans-differentiation

M Kassem, BM Abdallah, H Saeed - Archives of biochemistry and …, 2008 - Elsevier
The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC)
present among the bone marrow stroma. MSC are capable of multi-lineage differentiation …

Mesenchymal stem cells: mechanisms and role in bone regeneration

Y Qin, J Guan, C Zhang - Postgraduate Medical Journal, 2014 - academic.oup.com
Stimulating bone growth and regeneration, especially in patients with delayed union or non-
union of bone, is a challenge for orthopaedic surgeons. Treatments employed for bone …

Therapeutic potential of genetically modified adult stem cells for osteopenia

S Kumar, TR Nagy, S Ponnazhagan - Gene therapy, 2010 - nature.com
Adult stem cells have therapeutic potential because of their intrinsic capacity for self-
renewal, especially for bone regeneration. The present study shows the utility of ex vivo …

[HTML][HTML] Recent progresses in the treatment of osteoporosis

SS Li, SH He, PY Xie, W Li, XX Zhang, TF Li… - Frontiers in …, 2021 - frontiersin.org
Osteoporosis (OP) is a chronic bone disease characterized by aberrant microstructure and
macrostructure of bone, leading to reduced bone mass and increased risk of fragile …

Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repair

F Granero-Molto, JA Weis, L Longobardi… - Expert opinion on …, 2008 - Taylor & Francis
Background: Mesenchymal stem cells (MSC) are multipotent cells with the ability to
differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes …

Clinical applications of mesenchymal stem cells in the treatment of fracture non-union and bone defects

AS Shekkeris, PK Jaiswal… - Current Stem Cell …, 2012 - ingentaconnect.com
Bone defects resulting from trauma or resorption, whether physiological or pathological,
remain a major challenge in the management of patients. The limits of bone regeneration …

[HTML][HTML] Mesenchymal stem cells: amazing remedies for bone and cartilage defects

P Kangari, T Talaei-Khozani… - Stem Cell Research & …, 2020 - Springer
Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …