Repair and regeneration of bone requires mesenchymal stem cells that by self-renewal, are
able to generate a critical mass of cells with the ability to differentiate into osteoblasts that …

Osteoporosis is caused by pathologic factors such as aging, hormone deficiency or excess,
inflammation and systemic diseases like diabetes. Bone marrow stromal cells (BMSCs), the …

Introduction• Mesenchymal stem cells as skeletal stem cells‐Cultured or expanded MSCs‐
Native MSCs‐The neural crest origin of MSCs• Vascularization by endothelial progenitor …

Mesenchymal stem cells (MSCs), the non-hematopoietic progenitor cells, are multi-potent
stem cells from a variety of tissues with the capability of self-renewal, proliferation …

Compromised bone-regenerating capability following a long bone fracture is often the result
of reduced host bone marrow (BM) progenitor cell numbers and efficacy. Without surgical …

Introduction• Bone biology• The relevance of cell–cell interactions in bone tissue
engineering• Co‐culture models in bone tissue engineering‐Angiogenesis‐Osteochondral …

Osteoporosis is well known to be a poly-factorial skeletal disorder characterized by a low
bone mineral density (BMD) at which the risk of developing fracture is remarkably increased …

Objective Age-related bone loss is associated with significant changes in bone remodeling
characterized by decreased trabecular and periosteal bone formation relative to bone …

Abstract Purpose of Review Skeletal stem cells (SSCs) are considered to play important
roles in bone development and repair. These cells have been historically defined by their in …

Mortality caused by age-related bone fractures or osteoporosis is steadily increasing
worldwide as the population ages. The pace of the development of bone regeneration …