Sleep requires sleep-active neurons that depolarize to inhibit wake circuits. Sleep-active
neurons are under the control of homeostatic mechanisms that determine sleep need …

Sleep-active neurons depolarize during sleep to suppress wakefulness circuits. Wake-active
wake-promoting neurons in turn shut down sleep-active neurons, thus forming a bipartite flip …

Sleep is characterized by behavioral quiescence, homeostasis, increased arousal threshold,
and rapid reversibility. Understanding how these properties are encoded by a neuronal …

Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that
express GABA. However, little is known about how sleep neuron function is determined and …

Prolonged wakefulness leads to an increased pressure for sleep, but how this homeostatic
drive is generated and subsequently persists is unclear. Here, from a neural circuit screen in …

Background Sleep is an essential behavior that is found in all animals that have a nervous
system. Neural activity is thought to control sleep, but little is known about the identity and …

Across species, sleep is characterized by a complex architecture. Sleep deprivation is a
classic method to study the consequences of sleep loss, which include alterations in the …

Highlights▶ Caenorhabditis elegans sleep occurs during lethargus, a larval stage transition
period.▶ Sensory gating during C. elegans sleep occurs in sensory neurons.▶ C. elegans …

Sleep is evolutionarily conserved and required for organism homeostasis and survival.
Despite this importance, the molecular and cellular mechanisms underlying sleep are not …

How the homeostatic drive for sleep accumulates over time and is released remains poorly
understood. In Drosophila, we previously identified the R5 ellipsoid body (EB) neurons as …