Background The neglected parasitic infection Chagas disease is rapidly becoming a
globalised public health issue due to migration. There are only two anti-parasitic drugs …

Background During Trypanosoma cruzi infection, macrophages produce reactive oxygen
species (ROS) in a process called respiratory burst. Several works have aimed to elucidate …

Virulence of Trypanosoma cruzi depends on a variety of genetic and biochemical factors. It
has been proposed that components of the parasites' antioxidant system may play a key part …

The main consequence of oxidative stress is the formation of DNA lesions, which can result
in genomic instability and lead to cell death. Guanine is the base that is most susceptible to …

The American trypanosome Trypanosoma cruzi is exposed to toxic oxygen metabolites that
are generated by drug metabolism and immune responses in addition to those produced by …

Benznidazole (BZ) is the most commonly used drug for the treatment of Chagas disease.
Although BZ is known to induce the formation of free radicals and electrophilic metabolites …

Chagas disease and leishmaniasis are neglected tropical diseases caused by the
protozoan parasites Trypanosoma cruzi and Leishmania spp., respectively. They are among …

Chagas disease is a neglected tropical disease, which affects an estimate of 6‐7 million
people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic …

Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which
TcI is most abundantly noted in the sylvatic transmission cycle and considered the major …

Trypanosoma cruzi's antioxidant system is unique and relevant to the parasite. In this study,
quantitative assays were performed to determine cytosolic and mitochondrial tryparedoxin …