The past 10 years have seen new approaches to elucidating genetic pathways regulating
sleep. The emerging theme is that sleep-like states are conserved in evolution, with similar …

Major questions on the biology of sleep include the following: what are the molecular
functions of sleep; why can wakefulness only be sustained for defined periods before there …

Sleep is widely recognized as essential, but without a clear singular function. Inadequate
sleep impairs cognition, metabolism, immune function, and many other processes. Work in …

Sleep is nearly ubiquitous throughout the animal kingdom, yet little is known about how
ecological factors or perturbations to the environment shape the duration and timing of …

Sleep has been identified in all mammals and nonmammalian vertebrates that have been
critically evaluated. In addition, sleep‐like states have also been identified and described in …

Why we sleep remains one of the enduring unanswered questions in biology. At its core,
sleep can be defined behaviorally as a homeostatically regulated state of reduced …

Sleep remains one of the least understood phenomena in biology—even its role in synaptic
plasticity remains debatable. Since sleep was recognized to be regulated genetically …

It has been known for a long time that genetic factors affect sleep quantity and quality.
Genetic screens have identified several mutations that affect sleep across species, pointing …

Most behaviors manifest themselves through interactions with environments. Sleep,
however, is characterized by immobility and reduced responsiveness. Although nearly all …

Molecular and genetic approaches in several species have provided new insights into the
mechanisms of rest-activity and sleep-wake regulation. Many of these discoveries are …