In response to environments that cause cellular stress, animals engage in sleep behavior
that facilitates recovery from the stress. In Caenorhabditis elegans, stress-induced sleep …

Enhanced sleep in response to cellular stress is a conserved adaptive behavior across
multiple species, but the mechanism of this process is poorly understood. Drosophila …

During health, animal sleep is regulated by an internal clock and by the duration of prior
wakefulness. During sickness, sleep is regulated by cytokines released from either …

The genetic basis of sleep regulation remains poorly understood. In C. elegans, cellular
stress induces sleep through epidermal growth factor (EGF)-dependent activation of the EGF …

Although essential and conserved, sleep is not without its challenges that must be
overcome; most notably, it renders animals vulnerable to threats in the environment …

Sleep and wakefulness are fundamental behavioral states of which the underlying
molecular principles are becoming slowly elucidated. Transitions between these states …

Sleep is an essential behavioral state. It is induced by conserved sleep-active neurons that
express GABA. However, little is known about how sleep neuron function is determined and …

Sleep requires sleep-active neurons that depolarize to inhibit wake circuits. Sleep-active
neurons are under the control of homeostatic mechanisms that determine sleep need …

Background Sleep is an essential behavior that is found in all animals that have a nervous
system. Neural activity is thought to control sleep, but little is known about the identity and …

Among the most important decisions an animal makes is whether to engage in active
movement and feeding behavior or to become quiescent. The molecular signaling …