Pathological processes such as bacterial, viral and parasitic infections can generate a
plethora of responses such as, but not restricted to, oxidative stress that can be harmful to …

Trypanosoma cruzi, the causative agent of Chagas disease, is an obligatory intracellular
parasite with a digenetic life cycle. Due to the variety of host environments, it faces several …

Trypanosoma cruzi is the etiological agent of Chagas Disease, which affects 6–7 million
people worldwide. Since the early stages of infection and throughout its life cycle, the …

The conservation of genomic integrity and stability is essential for cell survival. DNA
Damage Responses (DDRs) are considered of paramount importance for all living beings …

Uracil-DNA glycosylase (UNG) initiates the base excision repair pathway by excising uracil
from DNA. We have previously shown that Trypanosoma brucei cells defective in UNG …

A wide variety of DNA lesions arise due to environmental agents, normal cellular
metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular …

Trypanosoma cruzi, a parasitic protozoan, is the etiological agent of Chagas disease, an
endemic and neglected pathology in Latin America. It presents a life cycle that involves a …

Genomes are affected by a wide range of damage, which has resulted in the evolution of a
number of widely conserved DNA repair pathways. Most of these repair reactions have been …

Trypanosoma cruzi is the etiologic agent of Chagas' disease. Infected cells with T. cruzi
activate several responses that promote unbalance of reactive oxygen species (ROS) that …

Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative
stress, leading to damage of several macromolecules such as DNA. There are many DNA …