A cancer develops when a cell acquires specific growth advantages through the stepwise
accumulation of heritable changes in gene function. Basically, this process is directed by …

Genomic deletion of tumor suppressor genes (TSGs) is a rite of passage for virtually all
human cancers. The synthetic lethal paradigm has provided a framework for the …

Deregulation of gene expression is a hallmark of cancer. Although genetic lesions have
been the focus of cancer research for many years, it has become increasingly recognized …

DNA methylation is commonly thought of as a “molecular lock” that leads to permanent gene
silencing. To investigate this notion, we tested 24 different histone deacetylase inhibitors …

Interest in epigenetics is now booming in all the biomedical fields. Initially, interest was
sparked within the field of cancer research with the finding of global DNA hypomethylation …

Chronic exposure to inducers of DNA base oxidation and single and double strand breaks
contribute to tumorigenesis. In addition to the genetic changes caused by this DNA damage …

Epigenetic gene silencing, and associated promoter CpG island DNA hypermethylation, is
an alternative mechanism to mutations by which tumor suppressor genes may be inactivated …

Transcriptional silencing associated with aberrant promoter hypermethylation is a common
mechanism of inactivation of tumor suppressor genes in cancer cells. To globally profile the …

Cancer was thought to be caused solely by genetic mutations in oncogenes and tumor
suppressor genes. In the last 35 years, however, epigenetic changes have been …

Background DNA methylation mediates gene silencing primarily by inducing repressive
chromatin architecture via a common theme of interaction involving methyl-CpG binding …