Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal
malignancies, with an approximate 10% five-year survival rate despite therapy. A plausible …

Background & Aims Pancreatitis starts with primarily sterile local inflammation that induces
systemic inflammatory response syndrome, followed by compensatory anti-inflammatory …

NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR)
innate immune receptor family, regulates inflammation and host defense against …

Studies in animal models and human subjects have shown that both innate and adaptive
immunity contribute to the pathogenesis of type 1 diabetes (T1D). Whereas the role of TLR …

In vitro data suggest that a subgroup of NLR proteins, including NLRP12, inhibits the
transcription factor NF-κB, although physiologic and disease-relevant evidence is largely …

The inflammasomes have an important role in connecting the detection of endogenous and
microbial danger signals to caspase-1 activation and induction of protective immune …

NLRP3, a member of nucleotide-binding domain-(NOD) like receptor family, can be found in
large varieties of immune and non-immune cells. Upon activation, the NLRP3, apoptosis …

Background: Pancreatic cancer is one of the cancers where anti-PD-L1/PD-1
immunotherapy has been unsuccessful. What confers pancreatic cancer resistance to …

The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs),
which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ) …

NOD-like receptor (NLR) proteins are intracellular innate immune sensors/receptors that
regulate immunity. This work shows that NLRX1 serves as a tumor suppressor in colitis …