Aging of red blood cells (RBCs) in vivo and in vitro represents a key biomedical issue.
Human RBCs have an approximate lifespan of 120 days in vivo. In most countries, the shelf …

The red blood cells (RBCs) aging process is considered as an issue of special scientific and
clinical interest. It represents a total of unidirectional, timedependent but not-necessarily …

Normal human red blood cells have an average life span of about 120 days in the circulation
after which they are engulfed by macrophages. This is an extremely efficient process as …

Background: Mature red blood cells lack protein synthesis and are unable to restore
inactivated enzymes, damaged cytoskeleton and membrane proteins. An oxidation …

The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and
molecular level. It is not only a matter of apparent simplicity in terms of biochemistry …

Background It has long been known that red blood cells comprise various subpopulations,
which can be separated through Percoll density gradients. Materials and methods In this …

One hypothesis to explain the age-dependent clearance of red blood cells (RBCs) from
circulation proposes that denatured/oxidized hemoglobin (hemichromes) arising late during …

Determination of the erythrocyte lifespan is a complex process affected by many cellular
parameters. In the present study we measured and characterised the red blood cell (RBC) …

Background Red blood cells collected in citrate-phosphate-dextrose can be stored for up to
42 days at 4 C in saline-adenine-glucose-mannitol additive solution. During this controlled …

Human red blood cells (RBC) have a well-defined lifespan of 120 days affected by many
cellular parameters. The aim of the present study was to investigate through a functional …