[HTML][HTML] Inflammation and cancer: triggers, mechanisms, and consequences

FR Greten, SI Grivennikov - Immunity, 2019 - cell.com
Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …

[HTML][HTML] Underlying causes and therapeutic targeting of the inflammatory tumor microenvironment

EA Comen, RL Bowman, M Kleppe - Frontiers in cell and …, 2018 - frontiersin.org
Historically, the link between chronic inflammation and cancer has long been speculated.
Only more recently, pre-clinical and epidemiologic data as well as clinical evidence all point …

[HTML][HTML] Immunity, inflammation, and cancer

SI Grivennikov, FR Greten, M Karin - Cell, 2010 - cell.com
Inflammatory responses play decisive roles at different stages of tumor development,
including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation …

Cancer-related inflammation: common themes and therapeutic opportunities

FR Balkwill, A Mantovani - Seminars in cancer biology, 2012 - Elsevier
Inflammatory cells and mediators are an essential component of the tumor
microenvironment. Inflammatory circuits can differ considerably in different tumors in terms of …

Inflammation: the incubator of the tumor microenvironment

D Denk, FR Greten - Trends in Cancer, 2022 - cell.com
An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

[HTML][HTML] Targeting inflammation as cancer therapy

M Wang, S Chen, X He, Y Yuan, X Wei - Journal of Hematology & …, 2024 - Springer
Inflammation has accompanied human beings since the emergence of wounds and
infections. In the past decades, numerous efforts have been undertaken to explore the …

The resolution of inflammation and cancer

J Rodriguez-Vita, T Lawrence - Cytokine & growth factor reviews, 2010 - Elsevier
Inflammation has long been thought to contribute to the development of cancer; however
there is also clear evidence that the immune system can recognize and eliminate cancer …

[HTML][HTML] A cytokine-mediated link between innate immunity, inflammation, and cancer

WW Lin, M Karin - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
It has been established that cancer can be promoted and/or exacerbated by inflammation
and infections. Indeed, chronic inflammation orchestrates a tumor-supporting …

Pathways connecting inflammation and cancer

P Allavena, C Garlanda, MG Borrello, A Sica… - Current opinion in …, 2008 - Elsevier
Chronic and persistent inflammation contributes to cancer development and can predispose
to carcinogenesis. Infection-driven inflammations are involved in the pathogenesis of …

[HTML][HTML] Inflammation and tumor progression: signaling pathways and targeted intervention

H Zhao, L Wu, G Yan, Y Chen, M Zhou… - Signal transduction and …, 2021 - nature.com
Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …