Highlights•The microbiome has a composite relationship with its human host through which
it modulates numerous biological functions.•The biosynthetic potential of the human …

The human microbiome is a complex aggregate of microorganisms, and their genomes exert
a number of influences crucial to the metabolic, immunologic, hormonal, and homeostatic …

The clock chime has started the third decade of this century and cancer remains one of the
most challenging unsolved health problems, although several successful strategies are now …

Recent clinical and pathological evidence have implicated the gut microbiota as a nexus for
modulating the homeostasis of the human body, impacting conditions from cancer and …

Over the last decade, mounting evidence has revealed the key roles of gut microbiota in
modulating the efficacy and toxicity of anticancer drugs, via mechanisms such as …

Targeting the microbiome, microbiota-derived metabolites, and related pathways represents
a significant challenge in oncology. Microbiome analyses have confirmed the negative …

Immunotherapy sometimes leads to stunning therapeutic success in a wide range of
cancers. However—except in melanoma, microsatellite instable (MSI) colorectal cancer …

Commensal microorganisms (the microbiota) live on all the surface barriers of our body and
are particularly abundant and diverse in the distal gut. The microbiota and its larger host …