Assessment of Multifactor Gene–Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors

JL Usset, R Raghavan, JP Tyrer, V McGuire… - … Biomarkers & Prevention, 2016 - AACR
Background: Many epithelial ovarian cancer (EOC) risk factors relate to hormone exposure
and elevated estrogen levels are associated with obesity in postmenopausal women …

The association between single nucleotide polymorphisms and ovarian cancer risk: A systematic review and network meta‐analysis

J Hu, Z Xu, Z Ye, J Li, Z Hao, Y Wang - Cancer Medicine, 2023 - Wiley Online Library
Background The relationship between single nucleotide polymorphisms (SNPs) and ovarian
cancer (OC) risk remains controversial. This systematic review and network meta‐analysis …

Identifying Sequence Variants of 18 Hereditary Ovarian Cancer‐Associated Genes in Chinese Epithelial Ovarian Cancer Patients

X Wu, Z Chen, P Ren, X Zhao, D Tang… - BioMed Research …, 2021 - Wiley Online Library
Objectives. The causes of ovarian cancer (OC) have been confirmed to be closely related to
genetic factors. Identifying sequence variants of hereditary ovarian cancer (HOC) …

Identification of six new susceptibility loci for invasive epithelial ovarian cancer

KB Kuchenbaecker, SJ Ramus, J Tyrer, A Lee… - Nature …, 2015 - nature.com
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer
(EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 …

Genome-wide meta-analyses of breast, ovarian, and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types

SP Kar, J Beesley, A Amin Al Olama, K Michailidou… - Cancer discovery, 2016 - AACR
Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic
basis, but this has not been investigated systematically by genome-wide association (GWA) …

[HTML][HTML] Ovarian cancer: genomic analysis

W Wei, D Dizon, V Vathipadiekal, MJ Birrer - Annals of Oncology, 2013 - Elsevier
Objectives Despite improvements in the management of ovarian cancer patients over the
last 30 years, there has been only a minimal improvement in overall survival. While targeted …

Implementation of Comprehensive Genomic Profiling in Ovarian Cancer Patients: A Retrospective Analysis

S Peleg Hasson, D Hershkovitz, L Adar, M Brezis… - Cancers, 2022 - mdpi.com
Simple Summary Ovarian cancer is the third most common gynecologic cancer and the
eighth most common cause of death from cancer in women. Comprehensive genomic …

[HTML][HTML] Molecular features as promising biomarkers in ovarian cancer

PA Bukłaho, J Kiśluk, N Wasilewska… - Advances in Clinical …, 2023 - advances.umw.edu.pl
Ovarian cancer (OC) is a global challenge for modern medicine, ranking 7 th for incidence
and the 8 th most common cause of mortality from cancers in women. Ovarian cancer has a …

Clinical impact of next-generation sequencing multi-gene panel highlighting the landscape of germline alterations in ovarian cancer patients

G Gurioli, G Tedaldi, A Farolfi, E Petracci… - International Journal of …, 2022 - mdpi.com
BRCA1 and BRCA2 are the most frequently mutated genes in ovarian cancer (OC) crucial
both for the identification of cancer predisposition and therapeutic choices. However …

[HTML][HTML] Prevalence of pathogenic germline variants detected by multigene sequencing in unselected Japanese patients with ovarian cancer

A Hirasawa, I Imoto, T Naruto, T Akahane… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Pathogenic germline BRCA1, BRCA2 (BRCA1/2), and several other gene variants
predispose women to primary ovarian, fallopian tube, and peritoneal carcinoma (OC) …