In the present chapter, we review some aspects of the biosynthesis of sesquiterpene
lactones and its regulation in different medicinal and aromatic plants used in the …

Sesquiterpene lactones (SLs) are one of the most diverse groups of secondary metabolites
that mainly have been observed in the Asteraceae. They are composed of a C 15 skeleton …

Metabolic engineering is an integrated bioengineering approach, which has made
considerable progress in producing terpenoids in plants and fermentable hosts. Here, the …

The therapeutic properties of complex terpenes often depend on the stereochemistry of their
functional groups. However, stereospecific chemical synthesis of terpenes is challenging. To …

Metabolic engineering of terpenoids in plants is a fascinating research topic from two main
perspectives. On the one hand, the various biological activities of these compounds make …

Artemisinin is a sesquiterpene lactone isolated from the aerial parts of Artemisia annua L.
plants. Besides being currently the best therapeutic against both drug-resistant and cerebral …

The antimalarial drug artemisinin is a natural product produced by the plant Artemisia
annua. Extracts of A. annua have been used in Chinese herbal medicine for over two …

Artemisinin, a novel and highly potent antimalarial drug, is produced from the plant Artemisia
annua L. with very low yields ranging from 0.01% to 0.8% on a dry-weight basis. This makes …

Artemisinin, a sesquiterpene lactone exhibiting effective antimalarial activity, is produced by
only Artemisia annua plant. A key step in artemisinin biosynthesis is the cyclization of …

In order to better understand the influence of sesquiterpene synthases on artemisinin yield
in Artemisia annua, the expression of some sesquiterpene synthases has been studied …