B‐lymphocyte contributions to human autoimmune disease
K Yanaba, JD Bouaziz, T Matsushita… - Immunological …, 2008 - Wiley Online Library
Autoimmunity results from abnormal B‐and T‐cell recognition of self‐antigens, which leads
to autoantibody production in many cases. Autoantibodies produced by B‐cell‐derived …
to autoantibody production in many cases. Autoantibodies produced by B‐cell‐derived …
[HTML][HTML] Pathogenic roles of B cells in human autoimmunity: insights from the clinic
F Martin, AC Chan - Immunity, 2004 - cell.com
The pathogenic roles of B cells in human autoimmune diseases involve a multitude of
mechanistic pathways and include the well-established contributions of autoantibodies and …
mechanistic pathways and include the well-established contributions of autoantibodies and …
B cells as a therapeutic target in autoimmune diseases other than rheumatoid arthritis
RJ Looney - Rheumatology, 2005 - academic.oup.com
Selective B-cell depletion with anti-CD20 therapy is a promising novel treatment option for
patients with refractory autoimmune disease. The anti-CD20 antibody, rituximab, is the first …
patients with refractory autoimmune disease. The anti-CD20 antibody, rituximab, is the first …
B cell immunobiology in disease: evolving concepts from the clinic
F Martin, AC Chan - Annu. Rev. Immunol., 2006 - annualreviews.org
The pathogenic roles of B cells in autoimmune diseases occur through several mechanistic
pathways that include autoantibodies, immune complexes, dendritic and T cell activation …
pathways that include autoantibodies, immune complexes, dendritic and T cell activation …
B cells in autoimmune diseases
CS Hampe - Scientifica, 2012 - Wiley Online Library
The role of B cells in autoimmune diseases involves different cellular functions, including the
well‐established secretion of autoantibodies, autoantigen presentation and ensuing …
well‐established secretion of autoantibodies, autoantigen presentation and ensuing …
Targeting B cells and plasma cells in autoimmune diseases: From established treatments to novel therapeutic approaches
A Merino‐Vico, G Frazzei… - European journal of …, 2023 - Wiley Online Library
Autoimmune diseases are characterized by the recognition of self‐antigens by the immune
system, which leads to inflammation and tissue damage. B cells are directly and indirectly …
system, which leads to inflammation and tissue damage. B cells are directly and indirectly …
Cytokine production by human B cells: role in health and autoimmune disease
NM de Gruijter, B Jebson… - Clinical and Experimental …, 2022 - academic.oup.com
B cells are classically considered solely as antibody-producing cells driving humoral
immune responses to foreign antigens in infections and vaccinations as well as self …
immune responses to foreign antigens in infections and vaccinations as well as self …
B‐cell targeted therapies in human autoimmune diseases: an updated perspective
MJ Townsend, JG Monroe, AC Chan - Immunological reviews, 2010 - Wiley Online Library
The advent of therapies that specifically target the B‐lymphocyte lineage in human disease
has rejuvenated interest in the mechanistic biology by which B cells mediate autoimmunity …
has rejuvenated interest in the mechanistic biology by which B cells mediate autoimmunity …
B-lymphocytes, innate immunity, and autoimmunity
M Viau, M Zouali - Clinical immunology, 2005 - Elsevier
Having evolved to generate a huge Ag-specific repertoire and to mount T cell-dependent
responses and long-term memory, the B lymphocyte is a central player in the adaptive …
responses and long-term memory, the B lymphocyte is a central player in the adaptive …
B cell targeted therapies in autoimmune disease
Purpose of review FDA-approved B cell-targeted therapy has expanded to a multitude of
autoimmune diseases ranging from organ specific diseases, like pemphigus and multiple …
autoimmune diseases ranging from organ specific diseases, like pemphigus and multiple …