New genetic markers for adult acute lymphoblastic leukemia (ALL) have been found to have
prognostic impact, such as the lymphoid transcription factor gene IKZF1 alterations, which …

Simple Summary The latest molecular taxonomy of acute lymphoblastic leukemia (ALL)
comprises> 20 distinct genetic subtypes, each with their own unique clinical and prognostic …

Contemporary treatments for acute lymphoblastic leukemia (ALL) can cure more than 80%
of children with this disease but fewer than 50% of adults. 1 Current risk-directed therapy is …

Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood and is
treated with chemotherapy alone or, in particular subgroups, with additional radiation …

Contemporary chemotherapy for childhood acute lymphoblastic leukemia (ALL) is risk-
adapted based on clinical features, leukemia genomics and minimal residual disease …

Background Acute lymphoblastic leukemia (ALL), the most common childhood malignancy,
is characterized by molecular aberrations. Recently, genetic profiling has been fully …

Acute lymphoblastic leukaemia occurs in both children and adults but its incidence peaks
between 2 and 5 years of age. Causation is multifactorial and exogenous or endogenous …

The outcome for children with acute lymphoblastic leukemia (ALL) has improved
dramatically with current therapy resulting in an event free survival exceeding 75% for most …

Genetic variants, including single-nucleotide polymorphisms (SNPs), are key determiners of
interindividual differences in treatment efficacy and toxicity in childhood acute lymphoblastic …

BACKGROUND Much progress has been made in understanding the biology of acute
lymphoblastic leukemia (ALL). This has translated into the recognition of several subgroups …