Epigenetic disorders such as point mutations in cellular tumor suppressor genes, DNA
methylation and post-translational modifications are needed to transformation of normal …

The correlation between chronic inflammation and cancer was initially identified in the 19th
century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors …

Purpose Cancer cells, despite stemming from the own cells of their host, usually elicit an
immune response. This response usually enables elimination of cancer at its earliest stages …

In many settings, tumor-associated inflammation, supported mainly by innate immune cells,
contributes to tumor growth. Initial innate activation triggers secretion of inflammatory …

Interactions between tumor infiltrating leukocytes and tumor cells have been of great interest
because of the possibility that immune cells either interfere with tumor progression or …

Abstract The Inflammation and Cancer Think Tank Meeting was organized by the National
Cancer Institute with the purpose of identifying research advances, gaps, and opportunities …

Clinical and experimental data now clearly indicate that chronic inflammation significantly
contributes to cancer development. Emerging out of these studies is an appreciation that …

Cells of the innate immune system have a dual role in cancer development in both tumor
initiation and progression. Innate immune cells can, on the one hand, aid malignant …

Inflammatory cells and mediators are an essential component of the tumor
microenvironment. Inflammatory circuits can differ considerably in different tumors in terms of …

Historically, the link between chronic inflammation and cancer has long been speculated.
Only more recently, pre-clinical and epidemiologic data as well as clinical evidence all point …