Components of the cellular and the humoral arm of the immune system are essential
elements of the tumour microenvironment (TME). The TME includes tumour‐associated …

An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

In the tumour microenvironment, cancer cells directly interact with both the immune system
and the stroma. It is firmly established that the immune system, historically believed to be a …

Cancers often arise as the end stage of inflammation in adults, but not in children. As such
there is a complex interplay between host immune cells during neoplastic development, with …

An intrinsic (oncogene‐driven) pathway and an extrinsic (microenvironment‐driven)
pathway connect inflammatory reactions and cancer. M2‐polarized tumor‐associated …

Chronic inflammation plays a pivotal role in cancer development. Cancer cells interact with
adjacent cellular components (pro-inflammatory cells, intrinsic immune cells, stromal cells …

Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …

Recent years have seen a renaissance in the research linking inflammation and cancer with
immune cells playing a central role in smouldering inflammation in the tumor …

Vicious cycle. Macrophages produce several substances that can enhance tumor growth,
including TNF-α, which can turn up NF-κB activity in both target tissue cells and in …

Inflammation is emerging as one of the hallmarks of cancer, yet its role in most tumors
remains unclear. Whereas a minority of solid tumors are associated with overt inflammation …