Tumor initiation, growth, and metastatic progression are complex processes that, in order to
be successful, require extraordinary cellular plasticity. Accordingly, tumor cell plasticity and …

The extremely delicate shift from an inflammatory process to tumorigenesis is a field of major
scientific interest. While the inflammation induced by environmental agents has well known …

Metastatic disease is the major challenge of cancer that accounts for over 90% of total
cancer lethality. Mounting clinical and preclinical data now indicate that inflammation, a …

Opposing effects of inflammation on cancer have been described. Acute inflammation
usually counteracts cancer development, while chronic inflammation promotes cancer …

Passive immunotherapy, including adoptive T-cell therapy and antibody therapy, has shown
encouraging results in cancer treatment lately. However, active immunotherapy of solid …

It has been increasingly recognized that tumor microenvironment plays an important role in
carcinogenesis. Inflammatory component is present and contributes to tumor proliferation …

Immunotherapies, signal transduction inhibitors and chemotherapies can successfully
achieve remissions in advanced stage cancer patients, but durable responses are rare …

During the last decade, it has become clear that the mammalian immune system is able to
recognize and partially suppress nascent tumors. Human T cells specific to oncogenes and …

Chronic inflammation plays a multifaceted role in carcinogenesis. Mounting evidence from
preclinical and clinical studies suggests that persistent inflammation functions as a driving …

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …