One possible intervention to interrupt the deleterious effects of the renin-angiotensin system
is suppression of angiotensin II (Ang II) formation by inhibition of angiotensin-converting …

The early and long-term effects of coronary artery ligation on the plasma and left ventricular
angiotensin-converting enzyme (ACE and ACE2) activities, ACE and ACE2 mRNA levels …

Blockade of the renin-angiotensin system by inhibition of angiotensin-converting enzyme
(ACE) is beneficial for the treatment of hypertension and congestive heart failure. However, it …

Fibroblasts play a pivotal role in cardiac remodeling and the development of heart failure
through the deposition of extra-cellular matrix (ECM) proteins and also by affecting …

Several intervention studies with angiotensin I converting enzyme (ACE) inhibitors have
demonstrated a remarkable improvement in the treatment of patients with primary …

Abstract Angiotensin converting enzyme 2 (ACE2), a newly recognized homolog of ACE that
converts angiotensin II (Ang II) to angiotensin-1–7 (Ang-(1–7)), is found in vascular smooth …

Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1R) blockers, current …

OBJECTIVES This study was designed to fully characterize vascular tissue angiotensin I
(AI)/angiotensin II (AII) conversion changes over time in vivo in humans during chronic …

Angiotensin‐converting enzyme 2 (ACE2) shares some homology with angiotensin‐
converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the …

The carboxypeptidase ACE2 is a homologue of angiotensin-converting enzyme (ACE). To
clarify the physiological roles of ACE2, we generated mice with targeted disruption of the …