The carboxypeptidase ACE2 is a homologue of angiotensin-converting enzyme (ACE). To
clarify the physiological roles of ACE2, we generated mice with targeted disruption of the …

Background—The added benefits of angiotensin II type I receptor (AT1) blockers (ARBs) to
ACE inhibition suggests that recommended doses of ACE inhibitors provide only partial …

Cardiovascular disease is predicted to be the commonest cause of death worldwide by the
year 2020. Diabetes, smoking and hypertension are the main risk factors. The renin …

The discovery of angiotensin-converting enzyme 2 (ACE2) in 2000 is an important event in
the renin-angiotensin system (RAS) story. This enzyme, an homolog of ACE, hydrolyzes …

INTRODUCTION: The beneficial effects of ACE inhibitors are generally ascribed to blockade
of neurohormonal activation. However, especially in chronic heart failure (CHF) patients …

Angiotensin-converting enzyme (ACE) plays a pivotal role in the renin-angiotensin system
(RAS) and ACE-inhibitors are widely used in several clinical conditions, including …

The RAS (renin–angiotensin system) is integral to cardiovascular physiology; however,
dysregulation of this system largely contributes to the pathophysiology of CVD …

OBJECTIVES We sought to demonstrate non-angiotensin converting enzyme (ACE)
dependent angiotensin II (AII) generating pathways in resistance arteries from patients with …

Background: The renin-angiotensin system is both a circulating and a local tissue hormonal
system. All components of the renin-angiotensin system have been found in important …

Angiotensin-converting enzyme 2 (ACE2) cleaves Angiotensin-II to Angiotensin-(1–7), a
cardioprotective peptide. Serum soluble ACE2 (sACE2) activity is raised in chronic heart …