BACKGROUND Storage of red blood cells (RBCs) under blood bank conditions promotes
metabolic modulation within the RBC. This “metabolic storage lesion” may affect the quality …

In vivo phagocytosis of senescent red blood cells (RBCs) by macrophages occurs 120 days
after their release into the circulation. It depends on two sequential signals that trigger …

Blood banking underpins modern medical care, but blood storage, necessary for testing and
inventory management, reduces the safety and efficacy of individual units of red blood cells …

Background. We used sensitive spectroscopic techniques to measure changes in Band 3
oligomeric state during storage of packed red blood cells (RBC); these changes were …

We have examined age-related changes in red cells by employing a serial hypertransfusion
protocol to generate populations of in vivo-aged mouse red cells. Studies of these old cells …

BACKGROUND: Storage of blood units (for 35–42 days, depending on the preservative
solution) has been reported to induce changes (eg, reduction of sialic acid level) in red cells …

Background Blood transfusion is an established therapeutic practice. The characteristics of
blood components at different storage times are expected to affect the efficacy of transfusion …

BACKGROUND Oxidative stress orchestrates a significant part of the red blood cell (RBC)
storage lesion. Considering the tremendous interdonor variability observed in the …

Anemia and hemorrhagic shock are leading causes of morbidity and mortality worldwide,
and transfusion of human blood products is the ideal treatment for these conditions. As …

Three intravenous injections (1mg each) of biotin-X-NHS (BXN) given at 24h intervals
labeled all circulating erythrocytes with biotin in C57Bl/6 mice. After 5 days, administration of …