Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide–cGMP and PI3K/mTOR pathways
Guanosine is an extracellular signaling molecule implicated in the modulation of
glutamatergic transmission and neuroprotection. The present study evaluated the …
glutamatergic transmission and neuroprotection. The present study evaluated the …
The antidepressant-like effect of guanosine is dependent on GSK-3β inhibition and activation of MAPK/ERK and Nrf2/heme oxygenase-1 signaling pathways
Although guanosine is an endogenous nucleoside that displays antidepressant-like
properties in several animal models, the mechanism underlying its antidepressant-like …
properties in several animal models, the mechanism underlying its antidepressant-like …
Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling
Guanosine is a purine nucleoside that has been shown to exhibit antidepressant effects, but
the mechanisms underlying its effect are not well established. We investigated if the …
the mechanisms underlying its effect are not well established. We investigated if the …
The antidepressant‐like effect of chronic guanosine treatment is associated with increased hippocampal neuronal differentiation
Guanosine is a purine nucleoside that occurs naturally in the central nervous system,
exerting trophic effects. Given its neuroprotective properties, the potential of guanosine as …
exerting trophic effects. Given its neuroprotective properties, the potential of guanosine as …
Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling
The activation of AMPA receptors and mTOR signaling has been reported as mechanisms
underlying the antidepressant effects of fast-acting agents, specially the NMDA receptor …
underlying the antidepressant effects of fast-acting agents, specially the NMDA receptor …
[HTML][HTML] Guanosine prevents behavioral alterations in the forced swimming test and hippocampal oxidative damage induced by acute restraint stress
Guanosine is a guanine-based purine that modulates glutamate uptake and exerts
neurotrophic and neuroprotective effects. In a previous study, our group demonstrated that …
neurotrophic and neuroprotective effects. In a previous study, our group demonstrated that …
Acute atorvastatin treatment exerts antidepressant-like effect in mice via the L-arginine–nitric oxide–cyclic guanosine monophosphate pathway and increases BDNF …
FK Ludka, ADE Zomkowski, MP Cunha… - European …, 2013 - Elsevier
Atorvastatin is a synthetic and lipophilic statin that presents a good effect in decreasing
cholesterol levels and is safe and well tolerated. Population-based studies have suggested …
cholesterol levels and is safe and well tolerated. Population-based studies have suggested …
Involvement of nitric oxide–cGMP pathway in the antidepressant-like effects of adenosine in the forced swimming test
We have previously shown that an acute administration of adenosine produces an
antidepressant-like effect in the forced swimming test (FST) and in the tail suspension test in …
antidepressant-like effect in the forced swimming test (FST) and in the tail suspension test in …
Possible involvement of nitric oxide (NO) signaling pathway in the anti-depressant-like effect of MK-801 (dizocilpine), a NMDA receptor antagonist in mouse forced …
A Dhir, SK Kulkarni - 2008 - nopr.niscpr.res.in
L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) is an important
signaling pathway involved in depression. With this information, the present study aimed to …
signaling pathway involved in depression. With this information, the present study aimed to …
[HTML][HTML] Systemic administration of GMP induces anxiolytic-like behavior in rats
RF Almeida, VHC Junior, RB Faraco… - Pharmacology …, 2010 - Elsevier
The glutamatergic system has received considerable attention over the last few years as
potential target to develop anxiolytic drugs. Guanine based purines (GBPs) play an …
potential target to develop anxiolytic drugs. Guanine based purines (GBPs) play an …
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