The innate immune system has evolved in multicellular organisms to detect and respond to
situations that compromise tissue homeostasis. It comprises a set of tissue-resident and …

Chronic inflammation increases the risk of several cancers, including gastric, colon, and
hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory …

Cells of the innate immune system have a dual role in cancer development in both tumor
initiation and progression. Innate immune cells can, on the one hand, aid malignant …

There is increasing clinical and experimental evidence that inflammation and cancer are
causally linked. Much progress has been made in understanding how inflammatory cells …

It has been established that cancer can be promoted and/or exacerbated by inflammation
and infections. Indeed, chronic inflammation orchestrates a tumor-supporting …

The relationship between inflammation and cancer has been recognized since the 17th
century, 1 and we now know much about the cells, cytokines and physiological processes …

Innate immune cells are active at the front line of host defense against pathogens and now
appear to play a range of roles under non-infectious conditions as well, most notably in …

The tumor microenvironment is shaped by interactions between tumor cells, stroma, and
immune cells. T cells are a critical component of the immunological anti-tumor response and …

A previously unappreciated cell type of the innate immune system, termed innate lymphoid
cells (ILCs), has been characterized in mice and humans and found to influence the …

The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive
and innate immune cells that have tumor-promoting and anti-tumor effects. There is still …