The importance of CD11c+ antigen-presenting cells (APCs) in the pathogenesis of
experimental autoimmune encephalomyelitis (EAE) is well accepted and the gate keeper …

In multiple sclerosis (MS), a demyelinating inflammatory disease of the CNS, and its animal
model (experimental autoimmune encephalomyelitis; EAE), circulating immune cells gain …

Neurodegeneration mediates neurological disability in inflammatory demyelinating diseases
of the CNS. The role of innate immune cells in mediating this damage has remained …

Neurodegenerative diseases are closely related to inflammatory and autoimmune events,
suggesting that the dysregulation of the immune system is a key pathological factor. Both …

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are closely
associated with neutrophil recruitment and activation, but the impact of the neutrophil …

INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …

Neuroinflammation is common to various diseases of the central nervous system (CNS), but
its imprecise definition has led to many misconceptions in research and clinical approaches …

In multiple sclerosis (MS), pathogenic T cell responses are known to be important drivers of
autoimmune inflammation. However, increasing evidence suggests an additional role for B …

In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis
(EAE) autoaggressive CD4+ T cells cross the blood–brain barrier (BBB) and cause …

There is great interest in understanding how the central nervous system (CNS)
communicates with the immune system for recruitment of protective responses. Infiltrating …