Glutamatergic system and mTOR-signaling pathway participate in the antidepressant-like effect of inosine in the tail suspension test
Glutamatergic system and mTOR signaling pathway have been proposed to be important
targets for pharmacological treatment of major depressive disorder. Previous studies have …
targets for pharmacological treatment of major depressive disorder. Previous studies have …
Signaling pathways underlying the antidepressant-like effect of inosine in mice
Inosine is a purine nucleoside formed by the breakdown of adenosine that elicits an
antidepressant-like effect in mice through activation of adenosine A 1 and A 2A receptors …
antidepressant-like effect in mice through activation of adenosine A 1 and A 2A receptors …
The antidepressant-like effect of inosine in the FST is associated with both adenosine A1 and A2A receptors
Inosine is an endogenous purine nucleoside, which is formed during the breakdown of
adenosine. The adenosinergic system was already described as capable of modulating …
adenosine. The adenosinergic system was already described as capable of modulating …
Guanosine produces an antidepressant-like effect through the modulation of NMDA receptors, nitric oxide–cGMP and PI3K/mTOR pathways
Guanosine is an extracellular signaling molecule implicated in the modulation of
glutamatergic transmission and neuroprotection. The present study evaluated the …
glutamatergic transmission and neuroprotection. The present study evaluated the …
The modulation of NMDA receptors and l-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test
The modulation of N-methyl-D-aspartate receptor (NMDAR) and l-arginine/nitric oxide (NO)
pathway is a therapeutic strategy for treating depression and neurologic disorders that …
pathway is a therapeutic strategy for treating depression and neurologic disorders that …
Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model
MN Quan, N Zhang, YY Wang, T Zhang, Z Yang - Neuroscience, 2011 - Elsevier
Glutamatergic processes are strongly implicated in the pathophysiology and treatment of
depression, including the antidepressant effects of N-methyl-d-aspartate (NMDA) receptor …
depression, including the antidepressant effects of N-methyl-d-aspartate (NMDA) receptor …
Inosine alleviates depression-like behavior and increases the activity of the ERK-CREB signaling in adolescent male rats
S Yuan, X Jiang, X Zhou, Y Zhang, T Teng, P Xie - Neuroreport, 2018 - journals.lww.com
Inosine, a major breakdown product of adenosine by the enzyme adenosine deaminase,
binds to adenosine receptors and initiates intracellular signaling events. Adenosine and …
binds to adenosine receptors and initiates intracellular signaling events. Adenosine and …
[HTML][HTML] Hyperforin potentiates antidepressant-like activity of lanicemine in mice
B Pochwat, B Szewczyk, K Kotarska… - Frontiers in Molecular …, 2018 - frontiersin.org
N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained
antidepressant like-activity in rodents through a molecular mechanism of action that involves …
antidepressant like-activity in rodents through a molecular mechanism of action that involves …
Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for involvement of N-methyl-D-aspartate receptors and the L-arginine-nitric …
M Mantovani, R Pértile, JB Calixto, ARS Santos… - Neuroscience …, 2003 - Elsevier
This study investigated the effect of melatonin in the mouse tail suspension test (TST), and
the contribution of N-methyl-d-aspartate (NMDA) receptors and the l-arginine-nitric oxide …
the contribution of N-methyl-d-aspartate (NMDA) receptors and the l-arginine-nitric oxide …
An anti-immobility effect of spermine in the forced swim test in mice
S Wośko, A Serefko, K Socała, B Szewczyk… - Pharmacological …, 2014 - Springer
Background Spermine is one of the naturally occurring ligands that influence the function of
the N-methyl-d-aspartate receptor. Similar to other endogenous polyamines present in …
the N-methyl-d-aspartate receptor. Similar to other endogenous polyamines present in …