Objective: The involvement of imidazoline receptors in the effect of agmatine was studied in
locomotor recovery following experimental SCI (ESCI) in mice. Methods: ESCI was induced …

Doxycycline is an antibiotic that has shown neuroprotective, anti-inflammatory, and
antidepressant-like effects. Low doses of doxycycline revert the behavioral and …

Hyperactivity of the hypothalamic pituitary–adrenal (HPA) axis plays a role in the
pathophysiology of major depressive disorder (MDD). Recent studies suggest the role of the …

Amantadine is a glutamatergic antagonist that works by inhibiting the NMDA receptor.
Besides the inhibition of NMDA receptors amantadine also stabilizes the glutamatergic …

Background Current antidepressants in clinical use always take weeks or even months to
exert full therapeutic effects, and sometimes have serious side effects. Thus, it is very …

Rationale Previously, we showed that pioglitazone exerts its antidepressant-like effect
through peroxisome proliferator-activated receptor gamma receptors and demonstrated the …

Imipramine, a major antidepressant, is known to inhibit reuptake of serotonin and
norepinephrine, which contributes to recovery from major depressive disorder. It has …

Arecoline is the principle psychoactive alkaloid in areca nuts. Areca nuts are chewable
seeds of Areca catechu L., which are epidemic plants that grow in tropical and subtropical …

The rapid antidepressant response to the N-methyl-d-aspartate (NMDA) receptor
antagonists is mediated by activation of the mammalian target of the rapamycin (mTOR) …

Although thought as a selective serotonin reuptake inhibitor (SSRI), the antidepressant
mechanisms of paroxetine remain unknown. Previous studies have shown the role of the …