Genomics in acute lymphoblastic leukaemia: insights and treatment implications

KG Roberts, CG Mullighan - Nature reviews Clinical oncology, 2015 - nature.com
Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer and an important
cause of morbidity from haematological malignancies in adults. In the past several years, we …

Genomic characterization of childhood acute lymphoblastic leukemia

CG Mullighan - Seminars in hematology, 2013 - Elsevier
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and a
leading case of childhood cancer death. The last decade has witnessed a transformation in …

Genomic characterization of paediatric acute lymphoblastic leukaemia: an opportunity for precision medicine therapeutics

SK Tasian, SP Hunger - British journal of haematology, 2017 - Wiley Online Library
Major advances in genetic and epigenetic profiling of acute lymphoblastic leukaemia (ALL)
have enhanced the understanding of key biological subsets of de novo and relapsed ALL …

Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine

SP Hunger, CG Mullighan - Blood, The Journal of the American …, 2015 - ashpublications.org
Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a
leading cause of cancer death in the young. In the last decade, microarray and sequencing …

Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions

CG Mullighan, JR Downing - Leukemia, 2009 - nature.com
Until recently, our understanding of the genetic factors contributing to the pathogenesis of
acute lymphoblastic leukemia (ALL) has relied on the detection of gross chromosomal …

Genetics and prognosis of ALL in children vs adults

KG Roberts - Hematology 2014, the American Society of …, 2018 - ashpublications.org
Acute lymphoblastic leukemia (ALL) is characterized by genetic alterations that block
differentiation, promote proliferation of lymphoid precursor cells, and are important for risk …

The molecular genetic makeup of acute lymphoblastic leukemia

CG Mullighan - Hematology 2010, the American Society of …, 2012 - ashpublications.org
Genomic profiling has transformed our understanding of the genetic basis of acute
lymphoblastic leukemia (ALL). Recent years have seen a shift from microarray analysis and …

Somatic and germline genomics in paediatric acute lymphoblastic leukaemia

CH Pui, KE Nichols, JJ Yang - Nature reviews Clinical oncology, 2019 - nature.com
Advances in genomic research and risk-directed therapy have led to improvements in the
long-term survival and quality of life outcomes of patients with childhood acute lymphoblastic …

The genomic landscape of acute lymphoblastic leukemia in children and young adults

CG Mullighan - Hematology 2014, the American Society of …, 2014 - ashpublications.org
Our understanding of the genetic basis of childhood acute lymphoblastic leukemia (ALL) has
been greatly advanced by genomic profiling and sequencing studies. These efforts have …

Childhood acute lymphoblastic leukemia: Integrating genomics into therapy

SK Tasian, ML Loh, SP Hunger - Cancer, 2015 - Wiley Online Library
Acute lymphoblastic leukemia (ALL), the most common malignancy of childhood, is a
genetically complex entity that remains a major cause of childhood cancer‐related mortality …