Background Although in recent years, the introduction of novel chemotherapy protocols has
improved the outcome of T cell acute lymphoblastic leukemia (T-ALL) patients, refractory …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant hematological
disorder arising in the thymus from T-cell progenitors. T-ALL mainly affects children and …

The major regulators of human acute lymphoblastic leukemia (ALL) cell growth and survival
mediate their effects through the phosphoinositide 3-kinase (PI-3K)/mammalian target of …

Recent findings have highlighted that constitutively active phosphatidylinositol 3-kinase
(PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling is a common feature of T-cell …

T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma (T-ALL/LBL) is a rare
hematologic malignancy most commonly affecting adolescent and young adult males …

Although significant improvements have been made in the treatment of acute lymphoblastic
leukemia (ALL), there is a substantial subset of high-risk T-cell ALL (T-ALL) patients with …

Purpose Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy
resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) …

Despite considerable progress in treatment protocols, B‐lineage acute lymphoblastic
leukemia (B‐ALL) displays a poor prognosis in about 15–20% of pediatric cases and about …

Constitutively active phosphoinositide 3-kinase (PI3K) signaling is a common feature of T-
cell acute lymphoblastic leukemia (T-ALL), where it upregulates cell proliferation, survival …

Introduction Nelarabine is a guanine nucleoside analog and functions to terminate DNA
synthesis in dividing cells. Pre-clinical and clinical studies have shown that it preferentially …