The functional capacity of cells is defined by the transcriptome. Many recent studies have
identified variations in the transcriptome of tumors due to alternative splicing changes, as …

Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Background Long-read sequencing of full-length cDNAs enables the detection of structures
of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated …

Abnormal alternative splicing has been associated with cancer. Genome-wide microarrays
can be used to detect differential splicing events. In this study, we have developed …

Alternative splicing represents a critical posttranscriptional regulation of gene expression,
which contributes to the protein complexity and mRNA processing. Defects of alternative …

Hotspot mutations in splicing factor genes have been recently reported at high frequency in
hematological malignancies, suggesting the importance of RNA splicing in cancer. We …

Although many driver mutations are thought to promote carcinogenesis via abnormal
splicing, the landscape of splicing-associated variants (SAVs) remains unknown due to the …

Over the past decade there has been increased awareness of the potential role of
alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing …

Alternative splicing is a key molecular mechanism for increasing the functional diversity of
the eukaryotic proteomes. A large body of experimental data implicates aberrant splicing in …

The robust detection of disease-associated splice events from RNAseq data is challenging
due to the potential confounding effect of gene expression levels and the often limited …