Highlights•Different melanogenesis signaling pathways.•Human tyrosinase inhibitors have
been discussed.•Drug repositioning has been applied to find new agents.Melanin, primarily …

Melanins are pigment molecules that determine the skin, eye, and hair color of the human
subject to its amount, quality, and distribution. Melanocytes synthesize melanin and provide …

Human skin, eye and hair color rely on the production of melanin, depending on its quantity,
quality, and distribution, Melanin plays a monumental role in protecting the skin against the …

Abnormally high production of melanin or melanogenesis in skin melanocytes results in
hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These …

Hyperpigmentation disorders constitute important medical and aesthetical conditions. Dark
areas or dark spots on the skin result from inappropriate amount and/or deposition of skin …

Human tyrosinase (hs TYR) is the key enzyme ensuring the conversion of l-tyrosine to
dopaquinone, thereby initiating melanin synthesis, ie, melanogenesis. Although the protein …

The skin containing melanin pigment acts as a protective barrier and counteracts the UVR
and other environmental stressors to maintain or restore disrupted cutaneous homeostasis …

Introduction: Melanogenesis is the process of producing the melanin pigment, in which a
series of chemical and enzymatic pathways are involved. Modulation at any level of this …

Melanin, the compound primarily responsible in humans for hair, eye and skin pigmentation,
is produced by melanocytes through a complicated process called melanogenesis that is …

Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human
skin. A key enzyme, tyrosinase, catalyzes the first and only rate-limiting steps in …