Background Hypothalamic centres have been recognized to play a central role in body
weight regulation for nearly 70 years. Aims In this review, we will explore the current …

Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic
neurons that transduce hormonal, nutrient and neuronal signals into responses that …

Context: Obesity has emerged as one of the leading medical challenges of the 21st century.
The resistance of this disorder to effective, long-term treatment can be traced to the fact that …

Appetite and body weight regulation are controlled by the central nervous system (CNS) in a
rather complicated manner. The human brain plays a central role in integrating internal and …

In the field of obesity research, two separate lines of study have emerged which explore the
mechanism by which food intake is regulated: short‐term control of food intake, and the …

New Findings What is the topic of this review? This report provides an overview of how
functional neuroimaging technology has accelerated our understanding of human eating …

The characterization of the hypothalamic neuronal network, that controls food intake and
energy expenditure, has provided great advances in the understanding of the …

Overconsumption of dietary fat contributes to the development of obesity and metabolic
syndrome. Recent evidence suggests that high dietary fat may promote these metabolic …

Emerging evidence from human imaging studies suggests that obese individuals have
altered connectivity between the hypothalamus, the key brain region controlling energy …

The increased incidence of obesity makes it imperative to understand the regulation of food
intake and body weight. We review the signals that interact with the brain to control energy …