Background Mycobacterium tuberculosis is characterised by limited genomic diversity,
which makes the application of whole genome sequencing particularly attractive for clinical …

Background Whole genome sequencing (WGS) is becoming an important part of
epidemiological investigations of infectious diseases due to greater resolution and cost …

Rationale Current tools available to study the molecular epidemiology of tuberculosis do not
provide information about the directionality and sequence of transmission for tuberculosis …

The control of tuberculosis depends on the identification and treatment of infectious patients
and their contacts, who are currently identified through a combined approach of genotyping …

Contact tracing complemented with genotyping is considered an important means of
understanding person-to-person transmission of tuberculosis (TB). It still remains unclear …

Background Whole genome sequencing provides better delineation of transmission clusters
in Mycobacterium tuberculosis than traditional methods. However, its ability to reveal …

Background Understanding Mycobacterium tuberculosis (Mtb) transmission is essential to
guide efficient tuberculosis control strategies. Traditional strain typing lacks sufficient …

Background Tuberculosis (TB) remains a serious public health threat worldwide.
Theoretically ultimate resolution of whole genome sequencing (WGS) for Mycobacterium …

Background Direct whole-genome sequencing of Mycobacterium tuberculosis from clinical
specimens will be a major breakthrough in tuberculosis diagnosis and control. To date …

Whole genome sequencing (WGS) of Mycobacterium tuberculosis has been used to trace
the transmission of M. tuberculosis, the causative agent of tuberculosis (TB). Previously …