p53 is an important tumor-suppressor protein that is mutated in more than 50% of cancers.
Strategies for restoring normal p53 function are complicated by the oncogenic properties of …

The mutant p53Y220C (mutp53Y220C) is frequently observed in numerous tumors,
including pancreatic cancer. The mutation creates a crevice in the DNA binding core domain …

Among genetic alterations in human cancers, mutations in the tumor suppressor p53 gene
are the most common, occurring in over 50% of human cancers. The majority of p53 …

Because of the dominant negative effect of mutant p53, there has been limited success with
wild-type (wt) p53 cancer gene therapy. Therefore, an alternative oligomerization domain for …

Loss of p53 tumor suppressor function is a key event in the genesis of most human tumors.
This observation has prompted efforts to restore p53 activity as an anticancer therapeutic …

The role of tumor suppressor protein p53 is undeniable in the suppression of cancer upon
oncogenic stress. It induces diverse conditions such as cell-cycle arrest, cell death, and …

TP53 is the most commonly mutated gene in cancer, with over half of all human cancers
harboring a mutation in the gene. The p53 protein is a transcription factor that functions as a …

The transcription factor p53 is known as the guardian of the genome for its powerful anti‐
tumour capacity. However, mutations of p53 that undermine their protein structure, resulting …

The tumor suppressor p53 is lost or mutated in approximately half of human cancers. Mutant
p53 not only loses its anti-tumor transcriptional activity, but also often acquires oncogenic …

The tumor suppressor p53 plays a critical role to preserve DNA fidelity from diverse insults
through the regulation of cell-cycle checkpoints, DNA repair, senescence and apoptosis …