Hypothalamic subregion alterations in anorexia nervosa and obesity: Association with appetite‐regulating hormone levels

H Alzaid, JJ Simon, G Brugnara… - … Journal of Eating …, 2024 - Wiley Online Library
Objective Anorexia nervosa (AN) and obesity are weight‐related disorders with imbalances
in energy homeostasis that may be due to hormonal dysregulation. Given the importance of …

Hypothalamic inflammation: is there evidence for human obesity?

RB Kumar, LJ Aronne - Current obesity reports, 2014 - Springer
With increasing awareness of the obesity epidemic have come research efforts to
understand the pathophysiology of body weight and appetite regulation. Clinical trials of diet …

Functional neuroimaging in craniopharyngioma: a useful tool to better understand hypothalamic obesity?

CL Roth, E Aylward, O Liang, NM Kleinhans, G Pauley… - Obesity facts, 2012 - karger.com
Objective: To use functional magnetic resonance imaging (fMRI) in craniopharyngioma (CP)
patients to examine the hypothesis that hypothalamic damage due to CP and its treatment …

Obesity is associated with hypothalamic injury in rodents and humans

JP Thaler, CX Yi, EA Schur, SJ Guyenet… - The Journal of …, 2012 - Am Soc Clin Investig
Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by
inflammation both in peripheral tissues and in hypothalamic areas critical for energy …

The role of corticostriatal–hypothalamic neural circuits in feeding behaviour: implications for obesity

RE Clarke, A Verdejo‐Garcia… - Journal of …, 2018 - Wiley Online Library
Emerging evidence from human imaging studies suggests that obese individuals have
altered connectivity between the hypothalamus, the key brain region controlling energy …

Loss of pons-to-hypothalamic white matter tracks in brainstem obesity

JQ Purnell, DL Lahna, MH Samuels… - International journal of …, 2014 - nature.com
Hyperphagia and obesity have been reported following damage to the hypothalamus in
humans. Other brain sites are also postulated to be involved in the control of food intake and …

The central nervous system control of energy homeostasis: High fat diet induced hypothalamic microinflammation and obesity

L Yan, J Li - Brain research bulletin, 2022 - Elsevier
Obesity is believed to arise through the imbalance of energy homeostasis controlled by the
central nervous system, where the hypothalamus plays the fundamental role in energy …

The neuropathology of obesity: insights from human disease

EB Lee, MP Mattson - Acta neuropathologica, 2014 - Springer
Obesity, a pathologic state defined by excess adipose tissue, is a significant public health
problem as it affects a large proportion of individuals and is linked with increased risk for …

Brain structural and functional alterations in individuals with combined overweight/obesity and mood disorders: A systematic review of neuroimaging studies

X Zhang, L Han, C Lu, RS McIntyre, KM Teopiz… - Journal of Affective …, 2023 - Elsevier
Growing evidence suggests there is a bidirectional relationship between depression and
obesity, which are associated with structural and functional brain abnormalities. However …

Neuroimaging and neuroendocrine insights into food cravings and appetite interventions in obesity

J Huang, C Wang, HB Zhang, H Zheng… - …, 2023 - academic.oup.com
This article reviews the previous studies on the distinction between food cravings and
appetite, and how they are regulated by hormones and reflected in brain activity. Based on …