The transmission and persistence of Mycobacterium tuberculosis within high risk
populations is a threat to tuberculosis (TB) control. In the current study, we used whole …

Whole genome sequencing (WGS) of Mycobacterium tuberculosis has been used to trace
the transmission of M. tuberculosis, the causative agent of tuberculosis (TB). Previously …

Background Understanding Mycobacterium tuberculosis (Mtb) transmission is essential to
guide efficient tuberculosis control strategies. Traditional strain typing lacks sufficient …

Few studies have used genomic epidemiology to understand tuberculosis (TB) transmission
in rural and remote settings–regions often unique in history, geography and demographics …

Tuberculosis (TB) control programs use whole-genome sequencing (WGS) of
Mycobacterium tuberculosis (Mtb) for detecting and investigating TB case clusters. Existence …

Background Whole genome sequencing (WGS) has rapidly become an important research
tool in tuberculosis epidemiology and is likely to replace many existing methods in public …

Background: Mycobacterium tuberculosis (MTB) has limited ability to acquire variability.
Analysis of its microevolution might help us to evaluate the pathways followed to acquire …

The Mycobacterium tuberculosis genome is more heterogenous and less genetically stable
within the host than previously thought. Currently, only limited data exist on the within-host …

Background Whole genome sequencing (WGS) has enabled the development of new
approaches to track Mycobacterium tuberculosis (Mtb) transmission between tuberculosis …

Transmission is a driver of tuberculosis (TB) epidemics in high-burden regions, with
assumed negligible impact in low-burden areas. However, we still lack a full characterization …