Haplotypic and Genotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia
Treatment-resistant schizophrenia (TRS) continues to be a challenge. It was related to
different factors, including alterations in the activity of brain dopaminergic system, which …
different factors, including alterations in the activity of brain dopaminergic system, which …
Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia
Antipsychotic drugs target primarily dopaminergic system which makes catechol-O-
methyltransferase (COMT) an interesting target in studies searching for treatment response …
methyltransferase (COMT) an interesting target in studies searching for treatment response …
Catechol-O-methyltransferase Val158Met polymorphism and clinical response to antipsychotic treatment in schizophrenia and schizo-affective disorder patients: a …
Background: The catechol-O-methyltransferase (COMT) enzyme plays a crucial role in
dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with …
dopamine degradation, and the COMT Val158Met polymorphism (rs4680) is associated with …
[HTML][HTML] Association between the COMT Val158Met polymorphism and antipsychotic efficacy in schizophrenia: An updated meta-analysis
Background Catechol-O-methyltransferase (COMT) contributes to the control of synaptic
dopamine (DA) transmission by catalyzing DA degradation in the presynaptic space. The …
dopamine (DA) transmission by catalyzing DA degradation in the presynaptic space. The …
The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on …
TB González-Castro, Y Hernández-Díaz… - Neuromolecular …, 2016 - Springer
An association between a catechol-O-methyltransferase (COMT) Val156Met (rs4680)
polymorphism and schizophrenia has been reported in the literature, although no conclusive …
polymorphism and schizophrenia has been reported in the literature, although no conclusive …
Association Studies of Catechol-O-Methyltransferase (COMT) Gene with Schizophrenia and Response to Antipsychotic Treatment
Aim: We investigated the catechol-O-methyltrasferase (COMT) gene, which is a strong
functional and positional candidate gene for schizophrenia and therapeutic response to …
functional and positional candidate gene for schizophrenia and therapeutic response to …
Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the …
Genetic variation in the catechol-O-methyltransferase (COMT) gene may influence the
susceptibility to schizophrenia and the response to neuroleptic treatment. The authors tested …
susceptibility to schizophrenia and the response to neuroleptic treatment. The authors tested …
Functional catechol-O-methyltransferase gene polymorphism and susceptibility to schizophrenia
TW Park, KS Yoon, JH Kim, WY Park… - European …, 2002 - Elsevier
Genetic polymorphism of catechol-O-methyltransferase (COMT), involved in the degradation
of catecholamine neurotransmitters, has been investigated as a candidate for modifier of …
of catecholamine neurotransmitters, has been investigated as a candidate for modifier of …
Meta-analysis of association between genetic variants in COMT and schizophrenia: an update
T Okochi, M Ikeda, T Kishi, K Kawashima… - Schizophrenia …, 2009 - Elsevier
A common functional polymorphism, Val108/158Met (rs4680), and haplotypes rs737865–
rs4680–rs165599 in the Catechol-O-methyltransferase gene (COMT) have been extensively …
rs4680–rs165599 in the Catechol-O-methyltransferase gene (COMT) have been extensively …
Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia
J Han, Y Li, X Wang - Neuropsychiatric disease and treatment, 2017 - Taylor & Francis
Objective The current study aimed to explore the association of single nucleotide
polymorphisms (SNPs) within catechol-O-methyltransferase (COMT) and dopamine …
polymorphisms (SNPs) within catechol-O-methyltransferase (COMT) and dopamine …
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