Several recent studies have used proportions of tuberculosis cases sharing identical DNA
fingerprint patterns (ie, isolate clustering) to estimate the extent of disease attributable to …

Background Tuberculosis (TB) is one of the major public health problems in Zambia.
However, information about lineages of M. tuberculosis complex (MTBC) isolates useful for …

Large-scale genotyping of Mycobacterium tuberculosis is especially challenging, as the
current typing methods are labor-intensive and the results are difficult to compare among …

The phylogeny and evolution of the bacterium Mycobacterium tuberculosis is still poorly
understood despite the application of a variety of molecular techniques. We analyzed 469 M …

Background RIFAQUIN was a tuberculosis chemotherapy trial in southern Africa including
regimens with high-dose rifapentine with moxifloxacin. Here, the application of whole …

Background Mycobacterium tuberculosis (MTB) has been classified into 4 main lineages.
Some reports have associated certain lineages with particular clinical phenotypes, but there …

In order to switch from IS 6110 and polymorphic GC-rich repetitive sequence (PGRS)
restriction fragment length polymorphism (RFLP) to 24-locus variable-number tandem …

The worldwide threat of tuberculosis to human health emphasizes the need to develop novel
approaches to a global epidemiological surveillance. The current standard for …

While high-copy-number IS 6110-based restriction fragment length polymorphism (HCN-
RFLP) is the gold standard for typing most Mycobacterium tuberculosis strains, the time …

Abstract Background. Genotyping Mycobacterium tuberculosis isolates allows study of
dynamics of tuberculosis transmission, while geoprocessing allows spatial analysis of …