Interest of cyclodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide

G Dufour, W Bigazzi, N Wong, F Boschini… - International journal of …, 2015 - Elsevier
To achieve an efficient lung delivery and efficacy, both active ingredient aerosolisation
properties and permeability through the lung need to be optimized. To overcome these …

[PDF][PDF] The effect of carrier particle size on adhesion, content uniformity and inhalation performance of budesonide using dry powder inhalers

W Kaialy, EH Larhrib, A Nokhodchi - 2012 - eprints.hud.ac.uk
Dry Powder Inhalers (DPIs) are the result of the development of two technologies: powder
technology and device technology. Particle deposition in the respiratory tract is affected by …

Engineering pharmaceutical fine particles of budesonide for dry powder inhalation (DPI)

TT Hu, H Zhao, LC Jiang, Y Le, JF Chen… - Industrial & engineering …, 2008 - ACS Publications
Budesonide, as one of the inhaled glucocorticosteroids, is widely used in the treatment of
asthma by pulmonary delivery. The purpose of this study was to prepare ultra-fine …

Engineering drug ultrafine particles of beclomethasone dipropionate for dry powder inhalation

LM Xu, QX Zhang, Y Zhou, H Zhao, JX Wang… - International journal of …, 2012 - Elsevier
Beclomethasone dipropionate (BDP), which is a member in the inhaled glucocorticosteroid
class, is commonly used in the treatment of asthma by pulmonary delivery. The purpose of …

Effect of processing history on the surface interfacial properties of budesonide in carrier-based dry-powder inhalers

J Shur, C Pitchayajittipong, P Rogueda… - Therapeutic …, 2013 - Taylor & Francis
Influence of air-jet micronization, post-micronization conditioning and storage on the surface
properties of budesonide in dry-powder inhaler formulations was investigated. Crystalline …

Coated particle assemblies for the concomitant pulmonary administration of budesonide and salbutamol sulphate

J Raula, A Rahikkala, T Halkola, J Pessi… - International journal of …, 2013 - Elsevier
The aims were to prepare stable and well-dispersible pulmonary fine powders composed of
combination drugs with different water solubility, to facilitate concomitant release of …

[HTML][HTML] Dual functional pullulan-based spray-dried microparticles for controlled pulmonary drug delivery

HY Li, EY Xu - International Journal of Pharmaceutics, 2023 - Elsevier
Two main challenges are associated with current spray-dried microparticles for inhalation,
including the enhancement of aerosolization performance of microparticles and the creation …

Inhalable microspheres with hierarchical pore size for tuning the release of biotherapeutics in lungs

A Sharma, K Vaghasiya, RK Verma - Microporous and Mesoporous …, 2016 - Elsevier
A series of customized inhalable mono-dispersed poly-L-lactide microspheres (PLA-MS)
having hierarchical pore structures with either open or closed porosity were synthesized by …

Improving Inhalation Performance with Particle Agglomeration via Combining Mechanical Dry Coating and Ultrasonic Vibration

Q Zhang, Z Wang, K Shi, H Zhou, X Wei, P Hall - Pharmaceutics, 2023 - mdpi.com
Agglomerate formulations for dry powder inhalation (DPI) formed with fine particles are
versatile means for the highly efficient delivery of budesonide. However, uncontrolled …

[HTML][HTML] Pulmonary targeting of levofloxacin using microsphere-based dry powder inhalation

T Al Hagbani, B Vishwa, AS Abu Lila, HF Alotaibi… - Pharmaceuticals, 2022 - mdpi.com
The objective of the current study was to develop poly (lactic-co-glycolic acid)(PLGA)
microspheres loaded with the anti-tuberculosis (anti-TB) fluoroquinolone, Levofloxacin …