CONCLUSIONS The DissolvIt system successfully differentiated between three compounds
with different physiochemical properties. In this study, differences in the rate of absorption …

The main purpose of this work was to develop an in vitro method for simulating the
dissolution and absorption of inhaled dry powder drugs that also mimics systemic …

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Dissolution cell Results and Discussion Dissolution of Orally Inhaled Drugs using DissolvIt® …

The surface area of the air/liquid interface in the lungs is substantial, so deposited doses of
aerosol medicines per interface surface area when administered via the inhalation route is …

To overcome some of the shortfalls of the types of dissolution testing currently used for
pulmonary products, a new custom-built dissolution apparatus has been developed. For …

This chapter describes several approaches that have been developed for the
characterization and understanding of the dissolution in the lung environment. Inhalation …

Pulmonary dissolution of poorly soluble drug substances (DSs) may limit the drug
absorption rate and consequently influence clinical performance. Dissolution rate is thus an …

In vitro dissolution testing is routinely used in the development of pharmaceutical products.
Whilst the dissolution testing methods are well established and standardized for oral dosage …

Pulmonary drug delivery has been used for decades to treat local diseases like asthma.
When using the pulmonary route to deliver drugs, several important lung features are being …

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, which
mainly affects the lungs. The current treatment by the oral or/and parenteral route of …